EstroG-100^® significantly alleviated menopausal symptoms after 12 weeks of supplementation, while 52 weeks of continuous use demonstrated an excellent long-term safety profile. In addition to sustained tolerability, long-term supplementation provided favorable effects on bone health and metabolic biomarkers without hormone replacement therapy (HRT)-related adverse effects or significant changes in body weight or circulating hormone levels. These findings support EstroG-100^® as a safe and effective non-hormonal option for the long-term management of menopausal symptoms.